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Can I Take Fish Oil And Vitamin B12 Together? Is It Safe And Beneficial?

By David Mercer

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This article was created after thorough research and has been improved with the assistance of AI technology. Furthermore, our dedicated editorial team has meticulously fact-checked and polished its content for accuracy and clarity.

It’s completely normal to have doubts about taking fish oil and vitamin B12 together. Don’t worry, you’re in the right place for your queries.

In the pursuit of optimal health, many individuals incorporate dietary supplements into their routines. Among the most popular choices are fish oil and vitamin B12, each offering unique benefits for the body. However, the question arises: Can these two supplements be taken together? Understanding the basics, potential interactions, and guidelines for combining fish oil and vitamin B12 is crucial for maximizing their health-promoting effects.

Key takeaways:

Vitamin B12 and fish oil can be taken together safely and provide synergistic benefits. B12 helps with the metabolism of the omega-3 fatty acids in fish oil.
Vitamin B12 is essential for maintaining healthy nerve function, preventing anemia, and supporting energy production, while fish oil’s omega-3s have anti-inflammatory effects that benefit heart, brain, and joint health.
The recommended daily intake is around 2.4 micrograms of B12 and 1-2 grams of combined EPA and DHA from fish oil for most adults, but individual needs may vary.

Vitamin B12, also known as cobalamin, is an essential nutrient that plays a vital role in various bodily functions. It is crucial for maintaining healthy nervous system function, aiding in the production of red blood cells, facilitating DNA synthesis, and supporting metabolic processes. Deficiency in B12 can lead to fatigue, anemia, and neurological issues.

Sources of B12 are primarily found in animal-derived foods such as meat, fish, dairy, and eggs. Individuals following a strict vegan or vegetarian diet, as well as those with conditions affecting nutrient absorption, may be at a higher risk of B12 deficiency.

Fish Oil And Vitamin B12

Fish oil is a rich source of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These essential fatty acids are renowned for their anti-inflammatory properties and have been linked to numerous health benefits.

Incorporating fish oil into one’s diet can contribute to improved heart health by lowering triglyceride levels, reducing blood pressure, and decreasing the risk of heart disease. Additionally, omega-3 fatty acids play a role in supporting brain function, and cognitive development, and potentially reducing the risk of certain neurological conditions.

While fish oil is commonly associated with fatty fish like salmon, tuna, and mackerel, plant-based sources of omega-3 fatty acids include walnuts, flaxseeds, and chia seeds.

How B12 And Fish Oil Work Together?

The synergistic effects of vitamin B12 and fish oil make their combination particularly beneficial for overall health. B12 plays a crucial role in the metabolism of fatty acids, including those derived from fish oil. By aiding in the metabolic process, B12 helps ensure that the body can effectively utilize the omega-3 fatty acids from fish oil.

Potential Risks Of Combining B12 And Fish Oil

While the combination of B12 and fish oil is generally considered safe, it is important to be aware of potential minor side effects and precautions. Some individuals may experience digestive discomfort, such as nausea or diarrhea, when taking high doses of fish oil. It is advisable to start with smaller doses and gradually increase intake to assess tolerance.

Individuals on blood-thinning medications should exercise caution when taking fish oil supplements, as omega-3 fatty acids may potentially increase the risk of bleeding. Consulting with a healthcare professional is recommended in such cases.

Absorption Process Of B12 And Fish Oil

Vitamin B12 is primarily absorbed in the small intestine through a complex process involving a protein called intrinsic factor. This protein binds to B12 and facilitates its absorption into the bloodstream.

Fish oil, on the other hand, is absorbed through the digestive system like other dietary fats. The fatty acids are broken down and transported to various tissues in the body, where they exert their beneficial effects.

Impact Of B12 And Fish Oil On Health

The combination of B12 and fish oil can have a profound impact on various bodily functions and systems. B12 is essential for maintaining healthy nerve function, preventing certain types of anemia, and supporting energy production.

Fish oil, with its rich omega-3 content, plays a crucial role in reducing inflammation throughout the body. This anti-inflammatory effect can contribute to improved cardiovascular health, better joint mobility, and potentially reduced risk of certain chronic diseases.

Additionally, omega-3 fatty acids from fish oil have been linked to improved cognitive function and brain health, making this combination particularly beneficial for overall mental well-being.

Recommended Dosages

The recommended daily intake for vitamin B12 is typically around 2.4 micrograms for adults. However, individuals with deficiencies or certain medical conditions may require higher doses as advised by a healthcare professional.

For fish oil, the optimal dosage can vary depending on individual needs and health goals. Generally, a daily intake of 1-2 grams of combined EPA and DHA from fish oil supplements is considered safe and beneficial for most adults.

It is essential to consult with a healthcare provider, especially if taking medications or dealing with specific health conditions, to determine the appropriate dosages for individual circumstances.

Best Time To Take B12 And Fish Oil

The optimal timing for taking B12 and fish oil supplements can vary based on personal preferences and digestive tolerance. Some individuals may find it easier to take fish oil with meals to minimize potential gastrointestinal discomfort.

For vitamin B12, it is generally recommended to take it with a meal or shortly after, as certain dietary factors can enhance its absorption.

To simplify the routine, many people choose to take both supplements together with a meal, ensuring consistent intake and maximizing the potential synergistic effects.


The combination of fish oil and vitamin B12 offers a powerful synergy of health benefits. While fish oil provides essential omega-3 fatty acids that contribute to reducing inflammation, supporting cardiovascular health, and promoting brain function, vitamin B12 plays a crucial role in metabolic processes, nervous system health, and red blood cell production.

By understanding the interactions and guidelines for taking these supplements together, individuals can maximize their potential benefits and support overall well-being. However, it is essential to consult with healthcare professionals for personalized advice, as individual circumstances and medical conditions may influence dosage recommendations.

Incorporating fish oil and vitamin B12 into a balanced diet, along with other nutrient-rich foods, can be a valuable step towards optimizing health and promoting longevity.

Remember, while dietary supplements can provide valuable nutritional support, they should be viewed as complements to a balanced and healthy diet, rather than replacements.


1. Is it OK to take B12 and omega-3 together?

Yes, it is generally safe to take vitamin B12 and omega-3 supplements together. They serve different purposes in the body and can complement each other’s benefits.

2. Can I take vitamins and fish oil at the same time?

Yes, it’s generally safe to take vitamins and fish oil supplements together. However, it’s always a good idea to consult with a healthcare professional for personalized advice.

3. What vitamin should not be taken with B12?

Vitamin C in large doses may interfere with the absorption of vitamin B12. However, consuming moderate amounts of vitamin C from foods or supplements is generally safe.

4. Is it OK to take vitamin B with fish oil?

Yes, it’s generally safe to take vitamin B supplements with fish oil. They serve different functions in the body and can be taken together as part of a balanced supplement regimen.


David Mercer

Dr. David Mercer is a board-certified physician in internal medicine and general practice. He has over 20 years of experience working in hospital settings, clinics, and private practice providing comprehensive care to patients.

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